Total synthesis of plakortide E and biomimetic synthesis of plakortone B
Description
In his thesis, Xiao-yu Sun conducts the first total synthesis of all possible stereoisomers of plakortide E and also confirms the absolute configuration of natural plakortide E. Xiao-yu Sun subsequently converts Plakortide E methyl ester to plakortone B in a biomimetic conversion. Construction and functionalization of cyclic peroxides are notoriously difficult due to the very low O-O bond dissociation energy. Plaktoride E is isolated from the Jamaican marine sponge platorits halichondrioides and contains a five-membered peroxide ring, with oxygen atoms linked to tertiary C4 and C6 centers. The methodology used for synthesizing highly substituted cyclic peroxides is novel and useful, and not only extends the field of Pd-catalyzed reactions, but also provides a convenient synthetic approach for the preparation of the 1,2-dioxolanes series. Plakortide E and plakortone B are bioactive, which means that the synthetic studies on them and their analogs are pivotal in drug discovery.
Subjects
Subjects
Academic theses
Chemistry
Chimie
dissertations
doctoral dissertations
Electronic books
masters theses
Nonfiction
Organic
Peroxides
Peroxides -- Synthesis
Peroxydes
Peroxydes -- Synthèse
Science
SCIENCE -- Chemistry -- Organic
Science des matériaux
Stereoisomers
Stereoisomers -- Synthesis
Stéréo-isomères
Stéréo-isomères -- Synthèse
Synthesis
Synthèse
theses
Thèses et écrits académiques
Chemistry
Chimie
dissertations
doctoral dissertations
Electronic books
masters theses
Nonfiction
Organic
Peroxides
Peroxides -- Synthesis
Peroxydes
Peroxydes -- Synthèse
Science
SCIENCE -- Chemistry -- Organic
Science des matériaux
Stereoisomers
Stereoisomers -- Synthesis
Stéréo-isomères
Stéréo-isomères -- Synthèse
Synthesis
Synthèse
theses
Thèses et écrits académiques
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ISBN:
9783642271953
9783642271946
9783642271946
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Grouping Information
Grouped Work ID | 9857afa9-5250-2981-3ad5-9f91a8982b0a |
---|---|
Grouping Title | total synthesis of plakortide e and biomimetic synthesis of plakortone b |
Grouping Author | xiao yu sun |
Grouping Category | book |
Grouping Language | English (eng) |
Last Grouping Update | 2024-05-16 19:20:46PM |
Last Indexed | 2024-05-17 23:34:27PM |
Solr Fields
accelerated_reader_point_value
0
accelerated_reader_reading_level
0
author
Sun, Xiao-Yu
author2-role
SpringerLink (Online service)
author_display
Sun, Xiao-Yu
available_at_ccu
CCU Electronic Resources
detailed_location_ccu
CCU Electronic Resources
display_description
In his thesis, Xiao-yu Sun conducts the first total synthesis of all possible stereoisomers of plakortide E and also confirms the absolute configuration of natural plakortide E. Xiao-yu Sun subsequently converts Plakortide E methyl ester to plakortone B in a biomimetic conversion. Construction and functionalization of cyclic peroxides are notoriously difficult due to the very low O-O bond dissociation energy. Plaktoride E is isolated from the Jamaican marine sponge platorits halichondrioides and contains a five-membered peroxide ring, with oxygen atoms linked to tertiary C4 and C6 centers. The methodology used for synthesizing highly substituted cyclic peroxides is novel and useful, and not only extends the field of Pd-catalyzed reactions, but also provides a convenient synthetic approach for the preparation of the 1,2-dioxolanes series. Plakortide E and plakortone B are bioactive, which means that the synthetic studies on them and their analogs are pivotal in drug discovery.
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eBook
format_ccu
eBook
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9857afa9-5250-2981-3ad5-9f91a8982b0a
isbn
9783642271946
9783642271953
9783642271953
itype_ccu
E-book
last_indexed
2024-05-18T05:34:27.216Z
lexile_score
-1
literary_form
Non Fiction
literary_form_full
Non Fiction
owning_library_ccu
Colorado Christian University Online
owning_location_ccu
CCU Electronic Resources
primary_isbn
9783642271953
publishDate
2012
publisher
Springer
recordtype
grouped_work
series
Springer theses
series_with_volume
Springer theses|
subject_facet
Academic theses
Chemistry
Chimie
Electronic books
Nonfiction
Peroxides -- Synthesis
Peroxydes -- Synthèse
SCIENCE -- Chemistry -- Organic
Science
Science des matériaux
Stereoisomers -- Synthesis
Stéréo-isomères -- Synthèse
Thèses et écrits académiques
dissertations
doctoral dissertations
masters theses
theses
Chemistry
Chimie
Electronic books
Nonfiction
Peroxides -- Synthesis
Peroxydes -- Synthèse
SCIENCE -- Chemistry -- Organic
Science
Science des matériaux
Stereoisomers -- Synthesis
Stéréo-isomères -- Synthèse
Thèses et écrits académiques
dissertations
doctoral dissertations
masters theses
theses
title_display
Total synthesis of plakortide E and biomimetic synthesis of plakortone B
title_full
Total synthesis of plakortide E and biomimetic synthesis of plakortone B / Xiao-Yu Sun
Total synthesis of plakortide e and biomimetic synthesis of plakortone b [electronic resource]. Xiao-yu Sun
Total synthesis of plakortide e and biomimetic synthesis of plakortone b [electronic resource]. Xiao-yu Sun
title_short
Total synthesis of plakortide E and biomimetic synthesis of plakortone B
topic_facet
Chemistry
Chimie
Nonfiction
Organic
Peroxides
Peroxydes
SCIENCE
Science
Science des matériaux
Stereoisomers
Stéréo-isomères
Synthesis
Synthèse
Chimie
Nonfiction
Organic
Peroxides
Peroxydes
SCIENCE
Science
Science des matériaux
Stereoisomers
Stéréo-isomères
Synthesis
Synthèse
Solr Details Tables
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external_econtent:ils:.b35217765 | .i71727310 | CCU Electronic Resources | eBook | eBook | 1 | false | true | SpringerLink CCU Owned | http://ezproxy.ccu.edu/login?url=http://dx.doi.org/10.1007/978-3-642-27195-3 | Available Online | cceb | ||
external_econtent:ils:.b35217765 | .i150304882 | CMU Electronic Access | Web Content | eBook | 1 | false | true | SpringerLink | http://ezproxy.coloradomesa.edu/login?url=https://link.springer.com/10.1007/978-3-642-27195-3 | Available Online | cueme |
record_details
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overdrivecmc:ODN0003557418 | eBook | eBook | English | 2012 | 1 online resource | |||
external_econtent:ils:.b35217765 | eBook | eBook | English | Springer | [2012] | 1 online resource (xiv, 220 pages) : color illustrations. |
scoping_details_ccu
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