Total synthesis of plakortide E and biomimetic synthesis of plakortone B
(eBook)
Author:
Series:
Published:
Berlin ; New York : Springer, ©2012., Berlin ; New York : Springer, [2012].
Format:
eBook
ISBN:
9783642271953, 3642271952, 3642271944, 9783642271946
Content Description:
1 online resource (xiv, 220 pages) : color illustrations.
Status:
Available Online
Description
In his thesis, Xiao-yu Sun conducts the first total synthesis of all possible stereoisomers of plakortide E and also confirms the absolute configuration of natural plakortide E. Xiao-yu Sun subsequently converts Plakortide E methyl ester to plakortone B in a biomimetic conversion. Construction and functionalization of cyclic peroxides are notoriously difficult due to the very low O-O bond dissociation energy. Plaktoride E is isolated from the Jamaican marine sponge platorits halichondrioides and contains a five-membered peroxide ring, with oxygen atoms linked to tertiary C4 and C6 centers. The methodology used for synthesizing highly substituted cyclic peroxides is novel and useful, and not only extends the field of Pd-catalyzed reactions, but also provides a convenient synthetic approach for the preparation of the 1,2-dioxolanes series. Plakortide E and plakortone B are bioactive, which means that the synthetic studies on them and their analogs are pivotal in drug discovery.
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Citations
APA Citation (style guide)
Sun, X. (2012). Total synthesis of plakortide E and biomimetic synthesis of plakortone B. Berlin ; New York, Springer.
Chicago / Turabian - Author Date Citation (style guide)Sun, Xiao-Yu. 2012. Total Synthesis of Plakortide E and Biomimetic Synthesis of Plakortone B. Berlin ; New York, Springer.
Chicago / Turabian - Humanities Citation (style guide)Sun, Xiao-Yu, Total Synthesis of Plakortide E and Biomimetic Synthesis of Plakortone B. Berlin ; New York, Springer, 2012.
MLA Citation (style guide)Sun, Xiao-Yu. Total Synthesis of Plakortide E and Biomimetic Synthesis of Plakortone B. Berlin ; New York, Springer, 2012.
Note! Citation formats are based on standards as of July 2022. Citations contain only title, author, edition, publisher, and year published. Citations should be used as a guideline and should be double checked for accuracy.
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Language:
English
UPC:
10.1007/978-3-642-27195-3
Notes
General Note
"Doctoral thesis accepted by The Chinese University of Hong Kong."
Dissertation
Ph. D.,Chinese University of Hong Kong
Bibliography
Includes bibliographical references.
Description
In his thesis, Xiao-yu Sun conducts the first total synthesis of all possible stereoisomers of plakortide E and also confirms the absolute configuration of natural plakortide E. Xiao-yu Sun subsequently converts Plakortide E methyl ester to plakortone B in a biomimetic conversion. Construction and functionalization of cyclic peroxides are notoriously difficult due to the very low O-O bond dissociation energy. Plaktoride E is isolated from the Jamaican marine sponge platorits halichondrioides and contains a five-membered peroxide ring, with oxygen atoms linked to tertiary C4 and C6 centers. The methodology used for synthesizing highly substituted cyclic peroxides is novel and useful, and not only extends the field of Pd-catalyzed reactions, but also provides a convenient synthetic approach for the preparation of the 1,2-dioxolanes series. Plakortide E and plakortone B are bioactive, which means that the synthetic studies on them and their analogs are pivotal in drug discovery.
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Grouped Work ID:
9857afa9-5250-2981-3ad5-9f91a8982b0a
Record Information
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| Last File Modification Time | Mar 20, 2024 05:28:27 PM |
| Last Grouped Work Modification Time | Mar 20, 2024 05:20:21 PM |
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| 505 | 0 | |a Introduction -- Results and Discussion -- Conclusion -- Experimental Section -- References -- Appendix I -- Appendix II. | |
| 520 | |a In his thesis, Xiao-yu Sun conducts the first total synthesis of all possible stereoisomers of plakortide E and also confirms the absolute configuration of natural plakortide E. Xiao-yu Sun subsequently converts Plakortide E methyl ester to plakortone B in a biomimetic conversion. Construction and functionalization of cyclic peroxides are notoriously difficult due to the very low O-O bond dissociation energy. Plaktoride E is isolated from the Jamaican marine sponge platorits halichondrioides and contains a five-membered peroxide ring, with oxygen atoms linked to tertiary C4 and C6 centers. The methodology used for synthesizing highly substituted cyclic peroxides is novel and useful, and not only extends the field of Pd-catalyzed reactions, but also provides a convenient synthetic approach for the preparation of the 1,2-dioxolanes series. Plakortide E and plakortone B are bioactive, which means that the synthetic studies on them and their analogs are pivotal in drug discovery. | ||
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